Resolution of enantiomers by HPLC on tris(4-alkoxyphenylcarbamate)s of cellulose and amylose
| Autor: | Toshiaki Ohashi, Yoshio Okamoto, Eiji Yashima, Yuriko Kaida |
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| Rok vydání: | 1993 |
| Předmět: |
inorganic chemicals
Pharmacology Tris Resolution (mass spectrometry) Organic Chemistry Cellulose derivatives High-performance liquid chromatography Catalysis Analytical Chemistry chemistry.chemical_compound chemistry Amylose Drug Discovery Alkoxy group Organic chemistry Cellulose Enantiomer Spectroscopy |
| Zdroj: | Chirality. 5:616-621 |
| ISSN: | 1520-636X 0899-0042 |
| Popis: | Ten phenylcarbamate derivatives of cellulose and amylose having alkoxy groups such as ethoxy, isopropoxy, and isobutoxy at 4-position, and methyl groups at 3- and 5-positions and methoxy group at 4-position were synthesized and their chiral recognition abilities as stationary phases for high-performance liquid chromatography were investigated and compared to those with tris(4-methoxyphenylcarbamate)s of cellulose and amylose. In 4-alkoxy derivatives of cellulose, chiral recognition ability increased as the bulkiness of 4-alkoxy groups increased. 4-Isopropoxy and 4-isobutoxy derivatives showed high chiral recognition. On the other hand, chiral discrimination of amylose 4-alkoxy derivatives scarcely depended on the bulkiness of the alkoxy group, and 4-methoxy and 4-isopropoxy derivatives showed high chiral recognition. 3,5-Dimethyl-4-methoxyphenylcarbamates of cellulose and amylose possessed higher chiral recognition ability than the corresponding 4-methoxy derivatives. © 1993 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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