Age and Disease Related Telomere Manifestations - A Review

Autor:	Nurul Fatihah Mohamad Nasir, Shaharum Shamsuddin, Azlina Ahmad, Stefan Stangaciu, Siti Amrah Sulaiman, Thirumulu Ponnuraj Kannan
Rok vydání:	2014
Předmět:	Senescence Premature aging Telomere-binding protein Telomerase Cell division DNA repair business.industry Medicine Shelterin business Virology Telomere Cell biology
Zdroj:	IOSR Journal of Dental and Medical Sciences. 13:63-68
ISSN:	2279-0853 2279-0861
DOI:	10.9790/0853-13626368
Popis:	Telomeres are long repetitive DNA sequences of TTAGGG located at the end of the linear chromosomes and bound by shelterin proteins. Shelterin proteins function as the protection for the loop structure of telomere, which prevents the chromosome ends uncapped; resemble a DNA break and activates DNA repair mechanism. Telomeres are maintained by an enzyme called telomerase. Telomerase is not expressed in normal human somatic cells. Therefore, telomeres shorten with every cell division and limit the number of cell division. This limitation of cell division is termed replicative aging, which is thought to be a barrier to cancer formation. In addition, telomere shortening can induce replicative senescence which then leads to aging and human aging-associated diseases such as cancer and atherosclerosis. Several studies on human premature aging diseases such as congenital dyskeratosis and aplastic anemia also reported association between them and telomere length.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58dcce48d3e9e9cd7bcf938baeb76fc7 https://doi.org/10.9790/0853-13626368 Zobrazit plný text záznamu