Update on Shigella and Nontyphoidal Salmonella Antimicrobial Drug Resistance: Implications on Empirical Treatment of Acute Infectious Diarrhea in Cambodia
| Autor: | Siriporn Sornsakrin, Heng Seng, Soklyda Chann, Sidonn Krang, Norman C. Waters, Brian Vesely, Sivhour Chiek, Sovann Ly, Aaron Farmer, Brett E. Swierczewski, Satharath Prom, Mariusz Wojnarski, Kamonporn Poramathikul, Worachet Kuntawunginn, Samandra T. Demons, Chanthap Lon, Vannara Sokh, Somethy Sok, Samon Nou, Woradee Lurchachaiwong, Paphavee Lertsethtakarn, Ladaporn Bodhidatta |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Salmonella Shigellosis medicine.drug_class business.industry Cephalosporin Drug resistance medicine.disease_cause medicine.disease Microbiology Multiple drug resistance Ciprofloxacin Infectious Diseases Antibiotic resistance medicine Pharmacology (medical) Shigella business medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 65 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Information on causative diarrheal pathogens and their associated antimicrobial susceptibility remains limited for Cambodia. This study describes antimicrobial resistance patterns for Shigella and nontyphoidal Salmonella isolates collected in Cambodia over a 5-year period. Multidrug resistance was shown in 98% of Shigella isolates, with 70%, 11%, and 29% of isolates being resistant to fluoroquinolones, azithromycin, and cephalosporin, respectively. As many as 11% of Shigella isolates were resistant to nearly all oral and parenteral drugs typically used for shigellosis, demonstrating extreme drug resistance phenotypes. Although a vast majority of nontyphoidal Salmonella isolates remained susceptible to cephalosporins (99%) and macrolides (98%), decreased susceptibility to ciprofloxacin was found in 67% of isolates, which is notably higher than previous reports. In conclusion, increasing antimicrobial resistance of Shigella and nontyphoidal Salmonella is a major concern for selecting empirical treatment of acute infectious diarrhea in Cambodia. Treatment practices should be updated and follow local antimicrobial resistance data for the identified pathogens. |
| Databáze: | OpenAIRE |
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