Cholecystokinetic activity of caerulein in sheep

Autor:	A.R. Calvari, C. Beretta, L. Leonardi, R. Faustini
Rok vydání:	1973
Předmět:	Pharmacology chemistry.chemical_classification medicine.medical_specialty Low dose Cholecystokinetic Peptide Reserpine Endocrinology chemistry Internal medicine medicine High doses Catecholamine medicine.drug
Zdroj:	Pharmacological Research Communications. 5:11-15
ISSN:	0031-6989
DOI:	10.1016/s0031-6989(73)80018-9
Popis:	Summary The cholecystokinetic properties of Caerulein in intact sheep show a good dose/effect relationship only when low doses of the peptide (1–10 ng/kg) are i.v. administered. At higher doses (100 ng/kg i.v.) the peptide show less activity. Pretreatment with reserpine or dibenamine strongly increases the cholecystokinetic effects of these doses and restores the dose/response relationship thus suggesting a catecholamine release produced by Caerulein when administered at high doses in sheep.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58d01701598426f99d1c73a19f421f71 https://doi.org/10.1016/s0031-6989(73)80018-9 Zobrazit plný text záznamu