Protective effect of leaf extract of Ficus hispida Linn. against paracetamol-induced hepatotoxicity in rats

Autor:	Subhash C. Mandal, B Saraswathi, S. Mohana Lakshmi, Bhim Chandra Maiti, C. K. Ashok Kumar
Rok vydání:	2000
Předmět:	Pharmacology biology Traditional medicine Bilirubin Moraceae biology.organism_classification Transaminase law.invention Acetaminophen chemistry.chemical_compound Alanine transaminase chemistry Biochemistry law biology.protein medicine Liver function Phytotherapy Ficus hispida medicine.drug
Zdroj:	Phytotherapy Research. 14:457-459
ISSN:	1099-1573 0951-418X
DOI:	10.1002/1099-1573(200009)14:6<457::aid-ptr610>3.0.co;2-8
Popis:	The methanol extract of the leaves of Ficus hispida Linn. (Moraceae) was evaluated for hepatoprotective activity in rats by inducing acute liver damage by paracetamol (750 mg/kg, p.o.). The extract at an oral dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of Liv-52 a known hepatoprotective formulation.
Databáze:	OpenAIRE
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