New phenol and chromone derivatives from the endolichenic fungus Daldinia species and their antiviral activities
| Autor: | Li-Yan Yu, Yujia Wang, Bingyuan Zhang, Sheng-Jun Dai, Jing-Lin Bai, Dewu Zhang, Guowei Gu, Yuang Fang, Shan Cen, Tao Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Circular dichroism
biology 010405 organic chemistry Stereochemistry General Chemical Engineering Daldinia sp General Chemistry Fungus biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Daldinia chemistry Chromone Ic50 values Phenol |
| Zdroj: | RSC Advances. 11:22489-22494 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/d1ra03754d |
| Popis: | Three new phenolic metabolites, daldispols A–C (1–3), two new chromone derivatives, (5R,7R)-5,7-dihydroxy-2-methyl-5,6,7,8-tetrahydro-4H-chromen-4-one (9) and (5R,7R)-5,7-dihydroxy-2-propyl-5,6,7,8-tetrahydro-4H-chromen-4-one (10), together with five known phenolic compounds (4–8) and two known chromone compounds (11 and 12) were isolated from the endolichenic fungus Daldinia sp. CPCC 400770. Their structures were elucidated on the basis of spectroscopic methods, electronic circular dichroism (ECD), and comparison with reported data. Compounds 1, 3, 4, 9, and 11 exhibited significant anti-influenza A virus (IAV) activities with IC50 values of 12.7, 6.4, 12.5, 16.1, and 9.0 μM, respectively, and compound 8 displayed significant anti-ZIKV activity with inhibitory ratio of 42.7% at 10 μM. The results demonstrated that the fungus Daldinia sp. CPCC 400770 might be a rich source for discovering anti-IAV secondary metabolites as potential novel leading compounds. |
| Databáze: | OpenAIRE |
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