Fruit and vegetable consumption,Helicobacter pyloriantibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea
| Autor: | Shoichiro Tsugane, Tianyi Wang, Wei Zheng, Hui Cai, Angelika Michel, Yu-Tang Gao, Meira Epplein, Shizuka Sasazuki, Eo Rin Cho, Wei-Cheng You, Michael Pawlita, Xiao-Ou Shu, Sun Ha Jee, Yong-Bing Xiang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine Prospective cohort study biology business.industry Cancer Odds ratio Helicobacter pylori medicine.disease biology.organism_classification digestive system diseases Confidence interval Surgery 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cohort Biomarker (medicine) business |
| Zdroj: | International Journal of Cancer. 140:591-599 |
| ISSN: | 0020-7136 |
| DOI: | 10.1002/ijc.30477 |
| Popis: | Epidemiological findings on the association between fruit and vegetable consumption and gastric cancer risk remain inconsistent. The present analysis included 810 prospectively ascertained non-cardia gastric cancer cases and 1,160 matched controls from the Helicobacter pylori Biomarker Cohort Consortium, which collected blood samples, demographic, lifestyle, and dietary data at baseline. Conditional logistic regression adjusting for total energy intake, smoking, and H. pylori status, was applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for gastric cancer risk across cohort- and sex-specific quartiles of fruit and vegetable intake. Increasing fruit intake was associated with decreasing risk of non-cardia gastric cancer (OR=0.71, 95% CI: 0.52-0.95, p-trend =0.02). Compared to low-fruit consumers infected with CagA-positive H. pylori, high-fruit consumers without evidence of H. pylori antibodies had the lowest odds for gastric cancer incidence (OR=0.12, 95% CI: 0.06-0.25), whereby the inverse association with high-fruit consumption was attenuated among individuals infected with CagA-positive H. pylori (OR=0.82, 95% CI: 0.66-1.03). To note, the small number of H. pylori negative individuals does influence this finding. We observed a weaker, non-dose-response suggestion of an inverse association of vegetable intake with non-cardia gastric cancer risk. High fruit intake may play a role in decreasing risk of non-cardia gastric cancer in Asia. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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