| Popis: |
A large single dose of ethanol (approximately 500 ml brand whisky) was administered to nine young, healthy males. This stimulus provoked pronounced increases in adrenaline and noradrenaline excretion during and soon after the ethanol ingestion. Similarly, the hangover next morning was accompanied by marked increases in adrenaline and noradrenaline excretion levels, in addition to increased excretion rates of 17-hydroxycorticosteroids. In five subjects treated with 0.5 g chlormethiazole, the catecholamine increases during the hang-over period were significantly reduced. During the week following the ethanol ingestion, the increase in adrenal function tended to persist. Some theoretical and clinical implications of these findings are discussed and some indications in favour of a relationship between the emotional-behavioural and the physiological effects of ethanol ingestion are mentioned. (Author) |
