A Practical Approach of Continuous Processing to High Energetic Nitration Reactions in Microreactors

Autor:	Thomas Schwalbe, Wolfgang Stirner, Gregor Wille, Gerhard Panke, Shahriyar Taghavi-Moghadam
Rok vydání:	2003
Předmět:	chemistry.chemical_compound Explosive material Chemistry Nitration Organic Chemistry Continuous reaction Organic chemistry Microreactor Toluene Catalysis
Zdroj:	Synthesis. :2827-2830
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-2003-42491
Popis:	Continuous processing in microreactors represents a novel way for the safe and expedient conduct of high energetic reactions and potentially hazardous chemistry. Apart from handling benefits (such as minimised problems inthe scale-up process), reactions in microreactors proceed under precisely controlled conditions providing improved yields and product quality compared to the batch procedure. In this paper, the potential of this technology is exemplarily determined in the crucial nitration of the pharmaceutically relevant intermediate 1-methyl-3-propyl-1H-pyrazole-5-carboxylic acid (1). Further fundamental nitration examples demonstrate the unproblematic handling of hazardous H 2 SO 4 / HNO 3 mixtures for the nitration of 2-methylindole (4) and pyridine-N-oxide (6) or even the explosive acetyl nitrate Ac 2 O/HNO 3 (nitration of toluene, 8) in the continuous reaction mode.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58b45d17f49ce2cb342af87328fd0562 https://doi.org/10.1055/s-2003-42491 Zobrazit plný text záznamu