Manufacture of l-amino acids with bioreactors

Autor:	Wayne E. Swann, Jacques J. Delente, Bruce King Hamilton, David M. Anderson, Humg-Yu Hsiao
Rok vydání:	1985
Předmět:	chemistry.chemical_classification Chromatography Chemistry technology industry and agriculture Bioengineering Phenylalanine equipment and supplies Cinnamic acid Amino acid Serine Titer chemistry.chemical_compound Aspartic acid Glycine Bioreactor Organic chemistry Biotechnology
Zdroj:	Trends in Biotechnology. 3:64-68
ISSN:	0167-7799
DOI:	10.1016/0167-7799(85)90079-4
Popis:	Several l -amino acids are currently manufactured by using enzymes or whole-cells contained within bioreactors. Production of l -aspartic acid in Japan is one of the earliest examples of this technology. A bioreactor method recently scaled-up for manufacture of l -phenylalanine from cinnamic acid and ammonia achieves product titers of over 60 g/l and a raw material conversion of about 90%. A bioreactor process in development for making l -serine from glycine and formaldehyde exploits rDNA technology and reaches an l -serine titer of over 400 g/l. The l -serine can be enzymatically converted to L-tryptophan to achieve a bioreactor titer of about 200 g/l.
Databáze:	OpenAIRE
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