Effect of nucleotides on the charge-transfer fluorescence of trans-4-(p-N,N-dimethylaminostyryl)-N-vinylbenzylpyridinium chloride

Autor:	Graham D. Darling, William S. Powell, Petra Turkewitsch, Rik R. Ganju, Barbara Wandelt
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Aqueous solution Chemistry Inorganic chemistry General Physics and Astronomy Quantum yield Fluorescence Chloride Medicinal chemistry Absorbance Bathochromic shift medicine Nucleotide Physical and Theoretical Chemistry Equilibrium constant medicine.drug
Zdroj:	Chemical Physics Letters. 260:142-146
ISSN:	0009-2614
DOI:	10.1016/0009-2614(96)00784-1
Popis:	Addition of the cyclic nucleotides cAMP and cGMP to aqueous solutions of trans-4-(p-N,N-dimethylaminostyryl)-N-vinylbenzylpyridinium chloride (1) dramatically enhanced the fluorescence quantum yield of 1 with concomitant slight red shifts of the λmax, and had slight hyperchromic and bathochromic effects on the absorbance of 1. In contrast, d -ribose-5-phosphate had no such effects. These results suggest that 1 preferentially associates with nucleotides in aqueous solution, with equilibrium constants for cAMP and cGMP of 212 ± 46 and 285 ± 18 M−1, respectively. Thus, dye 1 may serve as a starting point for the development of more sensitive and specific probes for cyclic nucleotides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58b2b82cb69f87bb95f268d5dd3e6248 https://doi.org/10.1016/0009-2614(96)00784-1 Zobrazit plný text záznamu Full Text from ScienceDirect