Brain docosahexaenoic acid accretion is greater when supplied as phosphatidylcholine than as triacylglycerol in piglets (821.11)
| Autor: | Peter Lawrence, Lei Liu, Kumar S.D. Kothapalli, Nana Bartke, Zhe Wang, Anthony Windust, Hui Park, Hans Van Daele, Xia Qin, J.T. Brenna |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty genetic structures Relative efficacy Phospholipid food and beverages Fatty acid Biochemistry Single oral dose chemistry.chemical_compound Endocrinology chemistry Docosahexaenoic acid Internal medicine Phosphatidylcholine Genetics medicine lipids (amino acids peptides and proteins) Brain Gray Matter Molecular Biology Biotechnology Polyunsaturated fatty acid |
| Zdroj: | The FASEB Journal. 28 |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | Introduction. Docosahexaenoic acid (DHA) is the most abundant n-3 PUFA in the brain. Preformed DHA is more efficacious for brain DHA accretion than precursors, but the relative efficacy of DHA bound to phospholipid (PC) and/or triacylglycerol (TAG) has not been measured yet. Our aim was to determine the relative efficacy of DHA when provided in formula to the growing piglet as a dose of 13C-DHA bound to the sn-2 positions of either PC or TAG. Methods. Piglets (n=8 per group) were assigned to two identical formula diets from day 3 of life and provided with a single oral dose of TAG-13C-DHA or PC-13C-DHA at 16 days of life. At day 23, selected piglet organs were analyzed for 13C-DHA and other fatty acid metabolites. Results. The PC-13C-DHA was 1.9-fold greater in brain gray matter than TAG-13C-DHA, and was similarly more efficacious in synaptosomes, retina, liver, and RBC. Liver labeling was by far the greatest implying initial processing in that organ followed by export to other organs, and in turn that tr... |
| Databáze: | OpenAIRE |
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