Mechanism of electrochemical oxidation of trimethoprim at pyrolytic graphite electrode

Autor:	Rekha Goyal, Anoop Kumar
Rok vydání:	1990
Předmět:	Chemistry Inorganic chemistry Electrode Electrochemistry Mass spectrum medicine Ph range Pyrolytic carbon Trimethoprim Analytical Chemistry medicine.drug
Zdroj:	Electroanalysis. 2:539-545
ISSN:	1521-4109 1040-0397
Popis:	The electrochemical oxidation behavior of trimethoprim has been investigated at a pyrolytic graphite electrode over a wide pH range (1.35–10.71). Below pH 3.2, trimethoprim is electrooxidized in two well-defined steps, each involving 4e, 4H+. Only one well-defined oxidation peak was observed above pH 3.5 however. Products corresponding to each peak have been separated and characterized by thin-layer chromatography (TLC), infra red (IR), and mass spectra. A tentative mechanism associated with the voltammetric oxidation has been proposed to account for the observed experimental behavior. The same product has also been observed during the metabolic oxidation of trimethoprim in albino rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58afc9cccb0fab1f7aa4c6b26eaf82c7 https://doi.org/10.1002/elan.1140020707 Zobrazit plný text záznamu Plný text