Mechanism of electrochemical oxidation of trimethoprim at pyrolytic graphite electrode
Autor: | Rekha Goyal, Anoop Kumar |
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Rok vydání: | 1990 |
Předmět: | |
Zdroj: | Electroanalysis. 2:539-545 |
ISSN: | 1521-4109 1040-0397 |
Popis: | The electrochemical oxidation behavior of trimethoprim has been investigated at a pyrolytic graphite electrode over a wide pH range (1.35–10.71). Below pH 3.2, trimethoprim is electrooxidized in two well-defined steps, each involving 4e, 4H+. Only one well-defined oxidation peak was observed above pH 3.5 however. Products corresponding to each peak have been separated and characterized by thin-layer chromatography (TLC), infra red (IR), and mass spectra. A tentative mechanism associated with the voltammetric oxidation has been proposed to account for the observed experimental behavior. The same product has also been observed during the metabolic oxidation of trimethoprim in albino rats. |
Databáze: | OpenAIRE |
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