Synthesis and in vitro anti-Helicobacter pylori activity of 2-[(chlorobenzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles

Autor:	Farideh Siavoshi, Bahram Letafat, Fatemeh Safari, Negar Mohammadhosseini, Abbas Shafiee, Saeed Emami, Alireza Foroumadi
Rok vydání:	2008
Předmět:	Inhibition zone biology Stereochemistry Chemistry Organic Chemistry Thio Helicobacter pylori biology.organism_classification In vitro Metronidazole Thiadiazoles medicine Nitro Moiety General Pharmacology Toxicology and Pharmaceutics medicine.drug
Zdroj:	Medicinal Chemistry Research. 17:578-586
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-008-9099-y
Popis:	A new series of 2-[(chlorobenzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles (6a–h) were synthesized and evaluated by the disc diffusion method against Helicobacter pylori. Four compounds which exhibited strong anti-H. pylori activity at concentration of 8–32 μg/disc (average of inhibition zone >20 mm) were further tested against 20 clinical isolates of H. pylori at lower concentrations. The averages of inhibition zone diameters indicated that all selected compounds exhibit better anti-H. pylori activity profile against clinical isolates of H. pylori with respect to standard drug metronidazole. Compound 6c, containing the 3-chlorobenzylthio moiety, was the most potent compound tested.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58adc32787fa70a39d24062f432f7851 https://doi.org/10.1007/s00044-008-9099-y Zobrazit plný text záznamu Full text from SpringerLink