Validation of a Capillary Electrophoresis Method for Analyzing Chlorphenamine Maleate-Based Drugs Using the Accuracy Profile Approach
| Autor: | Aminata Sarr, Bara Ndiaye, Serigne Omar Sarr, Rokhaya Sylla Gueye, Diop Amadou, Serigne Momar Ndiaye, Serge Rudaz, Yérim Mbagnick Diop, Ousmane Niass, El Hadji Assane Diop, Djibril Fall, Eddy Kevin Senan Ouendo, Thierno Mouhamed Wane, Khadidiatou Thiam |
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| Rok vydání: | 2016 |
| Předmět: |
Detection limit
Chromatography Chemistry 010401 analytical chemistry Analytical chemistry Repeatability Target concentration 030226 pharmacology & pharmacy 01 natural sciences 0104 chemical sciences 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Capillary electrophoresis Chlorphenamine maleate |
| Zdroj: | American Journal of Analytical Chemistry. :452-459 |
| ISSN: | 2156-8278 2156-8251 |
| DOI: | 10.4236/ajac.2016.75042 |
| Popis: | This study aimed at validating an analytical method, using the accuracy profile approach, for the assay of chlorphenamine maleate by capillary electrophoresis. The validation was done using concentrations ranging between 75% and 125% of the target concentration of 600 mg/ml. Validation standards were prepared separately in triplicate for each series. Studied validation criteria were selectivity, linearity, trueness, precision (repeatability and intermediate precision), accuracy and limits of detection and quantification. The method was selective, with recoveries ranging between 99.55% and 99.84%. The relative standard deviations of repeatability and intermediate precision were |
| Databáze: | OpenAIRE |
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