Synthesis and biological activity of N-(2-hydroxyethyl)cytisine derivatives

Autor:	A. R. Shaimuratova, M. S. Yunusov, D. V. Shishkin, N. S. Makara, Leonid V. Spirikhin, Vladimir A. Dokichev, N. Z. Baibulatova, Alexander N. Lobov, N. Zh. Baschenko
Rok vydání:	2007
Předmět:	Cytisine chemistry.chemical_compound chemistry Analgesic Organic chemistry Biological activity Plant Science General Chemistry General Biochemistry Genetics and Molecular Biology
Zdroj:	Chemistry of Natural Compounds. 43:190-196
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-007-0076-3
Popis:	Derivatives of N-(2-hydroxyethyl)cytisine, N-(2-hydroxypropyl)-, N-(2-hydroxy-2-(1-adamantyl)ethyl)-, and N-(2-hydroxy-2-phenylethyl)cytisine, were synthesized by reduction of N-(2-oxopropyl)-, N-(2-oxo-2-(1-adamantyl)ethyl)-and N-(2-oxo-2-phenylethyl)cytisine with metal hydrides. The antiarrhythmic and analgesic activities of the prepared compounds were investigated.
Databáze:	OpenAIRE
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