Detoxification potentials of an alcoholic bitter on carbon tetrachloride-induced oxidative damage in wistar albino rats
| Autor: | C. O. Ujowundu, V. A. Onwuliri, C. U. Igwe, C. S. Alisi, H.D. Ogbuagu, L. A. Nwaogu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology chemistry.chemical_classification Antioxidant Glutathione peroxidase medicine.medical_treatment Pharmaceutical Science Glutathione medicine.disease_cause Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Biochemistry Toxicity Carbon tetrachloride medicine Liver function Oxidative stress |
| Zdroj: | African Journal of Pharmacy and Pharmacology. 11:368-376 |
| ISSN: | 1996-0816 |
| DOI: | 10.5897/ajpp2017.4810 |
| Popis: | The increased demand for herbal remedies and natural quest for alcohol consumption has positioned alcoholic herbal preparations (bitters) as ideal drink. Bitters are acclaimed to have blood detoxifying and liver cleansing potentials. This study investigated the acclaimed detoxifying potentials of an alcoholic bitter (AB) on carbon tetrachloride (CCl4) induced toxicity. Twenty five male Wistar albino rats were grouped and treated, thus: group I served as normal control, groups II, IV and V were given single dose of 1.2 ml CCl4/kg body weight (bwt). Groups IV and V were administered 1.4 and 2.8 ml AB/kg bwt, respectively, while group III animals were administered 1.4 ml AB/kg bwt. Results obtained showed significant (p |
| Databáze: | OpenAIRE |
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