ChemInform Abstract: Synthesis of Topostins B567 and D654 (WB-3559D, Flavolipin), DNA Topoisomerase I Inhibitors of Bacterial Origin

Autor:	Naoko Irako, Yoshihiro Terao, Toyohiko Aoyama, Takayuki Shioiri
Rok vydání:	2010
Předmět:	DNA Topoisomerase I Inhibitors chemistry.chemical_classification chemistry.chemical_compound chemistry Bromide Stereochemistry Flavolipin Asymmetric hydrogenation chemistry.chemical_element Nanotechnology Peptide General Medicine Ruthenium
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199918223
Popis:	Topostins B567 (2b) and D654 (3b) (WB-3559D, flavolipin) have been efficiently synthesized from 1, 10-decanediol (5) in 11 and 13 steps, respectively, involving an asymmetric hydrogenation of the β-keto ester14 using(R)-BINAP ruthenium bromide and a peptide coupling using diethyl phosphorocyanidate (DEPC, (EtO)2P(O)CN) as key steps. Topostins B567 (2b) and D654 (3b) have been efficiently synthesized from 1, 10-decanediol (5) in 11 and 13 steps, respectively. Download : Download full-size image
Databáze:	OpenAIRE
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