| Autor: |
Farzad Rahmani, Mojde Atabati, Razieh Saber, Parnian Malakuti, Ghazaleh Pourali, Motahareh Heydari-majd, Pegah Safavi, Mohammad Dashti, Azam Rastgar Moghadam, Marjaneh Farazestanian, Negin Behboodi, Mehrane Mehramiz, Mohammadreza Nassiri, Majid Rajabian-Noghondar, Raheleh Rahbarian, Hassan Ramshini, Amirhosein Jafarian, Gordon A Ferns, Amir Avan, Malihe Hasanzadeh |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Current Cancer Therapy Reviews. 19 |
| ISSN: |
1573-3947 |
| Popis: |
Background: Cervical cancer is one of the most prevalent gynecologic cancers associated with high morbidity and mortality worldwide. There is mounting evidence indicating an association between the 9p21 locus genetic variants with susceptibility to various human malignancies. In this current study, we aimed to evaluate the potential relationship between the rs1333049 genetic variant in chromosome 9p21 and the risk of cervical carcinogenesis. background: Cervical cancer is one of the most prevalent gynecological cancers associated with high morbidity and mortality worldwide. There is mounting evidence indicating an association between the 9p21 locus genetic variants with susceptibility to various human malignancies. Method: The possible correlation between rs1333049 polymorphism and susceptibility to cervical cancer was investigated in 221 patients with or without cancer. DNAs were isolated and genotyped using a TaqMan-based real-time RT-PCR method. Result: The rs1333049 genetic variant was found to be correlated with an elevated risk of cervical neoplasia using recessive and additive genetic models (p method: The possible correlation between rs1333049 polymorphism and susceptibility to cervical cancer was investigated in 221 patients with, or without cancer. DNAs were isolated and genotyped using a TaqMan-based real-time RT-PCR method. Conclusion: CDKN2A/B genetic variant (rs1333049) was significantly associated with an elevated risk of cancer, suggesting its potential as a novel predictive marker for cervical carcinogenesis. other: . |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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