SAR study of the indole moiety of CI-988, a potent and selective CCK-B antagonist
| Autor: | N. Suman-Chauhan, Louise Webdale, Bharat K. Trivedi, Terri S. Purchase, Bruce D. Roth, Bradley Dean Tait, Michael W. Wilson, C.E. Augelli-Szafran |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Indole test Stereochemistry medicine.drug_class Organic Chemistry Clinical Biochemistry Antagonist Pharmaceutical Science Biological activity Receptor antagonist Biochemistry Chemical synthesis CI-988 chemistry Heterocyclic compound Drug Discovery medicine Molecular Medicine Moiety Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:2009-2014 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(97)00356-9 |
| Popis: | Due to the interesting pharmacological activity observed for CI-988, a potent and selective CCK-B receptor antagonist, we have continued to study the SAR of this antagonist. This particular study examines the importance of the indole moiety for binding affinity. The synthesis and receptor binding affinity for analogs containing functionalized indole derivatives and replacing the indole with various heterocycles are reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect