Octopamine receptors in the honey bee and locust nervous system: pharmacological similarities between homologous receptors of distantly related species

Autor:	Michael Gewecke, Joern Degen, Thomas Roeder
Rok vydání:	2000
Předmět:	Pharmacology animal structures biology Apidae Ecology Receptor expression media_common.quotation_subject fungi Insect Honey bee Octopamine (drug) biology.organism_classification chemistry.chemical_compound chemistry Mushroom bodies Receptor Neuroscience Locust media_common
Zdroj:	British Journal of Pharmacology. 130:587-594
ISSN:	0007-1188
DOI:	10.1038/sj.bjp.0703338
Popis:	1 Honey bees are perhaps the most versatile models to study the cellular and pharmacological basis underlying behaviours ranging from learning and memory to sociobiology. For both aspects octopamine (OA) is known to play a vital role. 2 The neuronal octopamine receptor of the honey bee shares pharmacological similarities with the neuronal octopamine receptor of the locust. Both, agonists and antagonists known to have high aAnities for the locust neuronal octopamine receptor have also high aAnities for the bee neuronal octopamine receptor. 3 The distribution of receptors is more or less congruent between locusts and bees. Optic lobes and especially the mushroom bodies are areas of greatest octopamine receptor expression in both species, which mirrors the physiological significance of octopamine in the insect nervous system. 4 The neuronal octopamine receptor of insects served as a model to study the pharmacological similarity of homologous receptors from distantly related species, because bees and locusts are separated by at least 330 million years of evolution. British Journal of Pharmacology (2000) 130, 587‐594
Databáze:	OpenAIRE
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