Genotoxic and antigenotoxic potential of the aqueous leaf extracts of Amaranthus spinosus Linn. using Allium cepa assay
| Autor: | V. Prajitha, J.E. Thoppil |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
0301 basic medicine Mitotic index Aqueous solution biology Traditional medicine Mutagen Plant Science Meristem biology.organism_classification medicine.disease_cause 01 natural sciences Oxidative damage 03 medical and health sciences 030104 developmental biology Botany medicine Allium Genotoxicity 010606 plant biology & botany |
| Zdroj: | South African Journal of Botany. 102:18-25 |
| ISSN: | 0254-6299 |
| Popis: | The aim of the present study was to evaluate the possible genotoxic effects of A. spinosus leaf extracts on Allium cepa root meristematic cells and its antigenotoxic effects against H 2 O 2 -induced genetic damage in A . cepa . The excessive reduction in mitotic index (MI) (A4, 3 h, 23.37 ± 1.41) and extremely significant ( P 2 O 2 . Higher percentage of nuclear lesions in treatment with H2O2 (99.27 ± 0.19) and its significant reduction after modulatory treatment (5 mg/L; 32.25 ± 7.69) was observed in the results, and indicates the chemopreventive activity of the plant extract at a critical concentration (5 mg/L). Here, the extent of antimutagenicity at this specific concentration (5 mg/L) was strong as the percentage of inhibition was greater than 40% (67.51 ± 8.68). The results demonstrated that the aqueous plant extract of A . spinosus have the ability to inhibit the oxidative damage induced by the direct-acting mutagen (H 2 O 2 ) at a precise concentration. |
| Databáze: | OpenAIRE |
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