ChemInform Abstract: Chiral Induction in Cycloaddition Reactions of Azomethine Ylides Derived from Secondary α-Amino Acids by the Decarboxylative Route

Autor:	Thomas Coulter, R. Grigg, Visuvanathar Sridharan, John F. Malone
Rok vydání:	2010
Předmět:	State model chemistry.chemical_classification Acrylate chemistry.chemical_compound chemistry Isatin Azomethine ylide General Medicine Single crystal Medicinal chemistry Cycloaddition Amino acid Chiral induction
Zdroj:	ChemInform. 23
ISSN:	0931-7597
DOI:	10.1002/chin.199223057
Popis:	Cyclic secondary α-amino acids react with isatin and menthyl acrylate via decarboxylative azomethine ylide formation and subsequent cycloaddition involving an endo-transition state to give cycloadducts in 67-82% d.e. The stereochemistry of the major cycloadduct is assigned from a single crystal X-ray structure and a transition state model is proposed for the process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5881d4c0853d691de231af3bc803a4b3 https://doi.org/10.1002/chin.199223057 Zobrazit plný text záznamu Plný text