Idiotype selection is an immunoregulatory mechanism which contributes to the pathogenesis of systemic lupus erythematosus

Autor:	Niver Panosian-Sahakian, Joan L. Klotz, Dale G. Ando, Bevra H. Hahn, Betty P. Tsao, Fanny M. Ebling, Mitchell Kronenberg, Kenneth C. Kalunian
Rok vydání:	1988
Předmět:	Idiotype Pathogenesis Immune system Downregulation and upregulation biology Mechanism (biology) Polyclonal antibodies Immunology Autoantibody biology.protein Immunology and Allergy Antibody
Zdroj:	Journal of Autoimmunity. 1:673-681
ISSN:	0896-8411
Popis:	Several experiments are reviewed to support the following suggestions: (1) Idiotypes can be used to identify pathogenic autoantibodies in murine and human systemic lupus erythematosus; (2) Those idiotypes are targets for immune upregulation which causes them to expand and dominate immunoglobulin responses; (3) Those idiotypes require autoreactive T-cell help; and (4) Both T cells and B cells participating in this response are polyclonal. These observations are used to construct an hypothesis to explain the sustained production of pathogenic autoantibody subsets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::587f406f5b1820ac7ef3ab749a8f21dd https://doi.org/10.1016/0896-8411(88)90058-3 Zobrazit plný text záznamu