Comparing outcome of radiofrequency ablation in Barrett’s with high grade dysplasia and intramucosal carcinoma: a prospective multicenter UK registry
| Autor: | Grant Fullarton, Jason M. Dunn, Charles Gordon, Praful Patel, A Gupta, Manuel Rodriguez-Justo, Howard Smart, Dermot O'Toole, Neil Kapoor, M Fullard, Marco Novelli, Vinay Sehgal, Yeng Ang, Ravi Narayanasamy, J Morris, H Barr, Pradeep Bhandari, Philip Boger, Brinder Mahon, Ian D. Penman, Natalie C. Direkze, Rehan Haidry, Danielle Morris, David Nyalender, Andrew Veitch, Haroon Miah, Edward Cheong, Rami Sweis, Laurence Lovat, Anjan Dhar, Matthew R. Banks, Massimo Di Pietro, Mohammed A. Butt, Gideon Lipman, Robert P. Willert, David Graham, Krish Ragunath, A Leahy, J Hoare |
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| Rok vydání: | 2015 |
| Předmět: |
education.field_of_study
medicine.medical_specialty business.industry Radiofrequency ablation Population Gastroenterology Cancer Intestinal metaplasia Endoscopic mucosal resection medicine.disease law.invention Surgery surgical procedures operative medicine.anatomical_structure Dysplasia law medicine Adenocarcinoma Esophagus business education |
| Zdroj: | Endoscopy. 47:980-987 |
| ISSN: | 1438-8812 0013-726X |
| DOI: | 10.1055/s-0034-1392414 |
| Popis: | BACKGROUND AND STUDY AIM Mucosal neoplasia arising in Barrett's esophagus can be successfully treated with endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA). The aim of the study was to compare clinical outcomes of patients with high grade dysplasia (HGD) or intramucosal cancer (IMC) at baseline from the United Kingdom RFA registry. PATIENTS AND METHODS Prior to RFA, visible lesions and nodularity were removed entirely by EMR. Thereafter, patients underwent RFA every 3 months until all visible Barrett's mucosa was ablated or cancer developed (end points). Biopsies were taken at 12 months or when end points were reached. RESULTS A total of 515 patients, 384 with HGD and 131 with IMC, completed treatment. Prior to RFA, EMR was performed for visible lesions more frequently in the IMC cohort than in HGD patients (77 % vs. 47 %; P |
| Databáze: | OpenAIRE |
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