Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis

Autor:	Cynthia R. Hill, Britni Jacobs, Steven Goudy, Christopher B. Brown, Joey V. Barnett
Rok vydání:	2014
Předmět:	medicine.medical_specialty Osteoblast Transforming growth factor beta Biology Bone morphogenetic protein 2 Cell biology Endocrinology medicine.anatomical_structure Internal medicine medicine biology.protein Receptor Gene Developmental Biology Transforming growth factor
Zdroj:	Developmental Dynamics. 244:122-133
ISSN:	1058-8388
Popis:	Background Cleft palate occurs in up to 1:1000 live births and is associated with mutations in multiple genes. Palatogenesis involves a complex choreography of palatal shelf elongation, elevation, and fusion. Transforming growth factor β (TGFβ) and bone morphogenetic protein 2 (BMP2) canonical signaling is required during each stage of palate development. The type III TGFβ receptor (TGFβR3) binds all three TGFβ ligands and BMP2, but its contribution to palatogenesis is unknown.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::586c7a276f177a3368c8d65790ef2efe https://doi.org/10.1002/dvdy.24225 Zobrazit plný text záznamu Plný text