Generation of urinary steroid profiles in patients with adrenal incidentaloma using gas chromatography–mass spectrometry
| Autor: | A. L. Moskvin, Z R Shafigullina, E V Obedkova, E. G. Strel’nikova, N. S. Krivokhizhina, V. G. Povarov, L I Velikanova, K Grigoryan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Chromatography Chemistry Incidentaloma medicine.medical_treatment Urinary system Analytical chemistry 030209 endocrinology & metabolism Urine Analytical Chemistry Steroid 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine Sample preparation Gas chromatography Gas chromatography–mass spectrometry Hormone |
| Zdroj: | Journal of Analytical Chemistry. 71:748-754 |
| ISSN: | 1608-3199 1061-9348 |
| Popis: | A method is developed for the determination of steroid hormones in urine using gas chromatography with mass-spectrometric detection. Sample preparation procedure and the conditions of chromatographic analysis were optimized, and characteristic urinary steroid profiles of patients with adrenocortical cancer were obtained. Criteria for the evaluation of the deficiency of 21-hydroxylase and 11β-hydroxylase in patients with adrenal incidentaloma are proposed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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