Serum interleukin-6 has no discriminatory role in paraproteinaemia nor a prognostic role in multiple myeloma
| Autor: | C. G. Schaar, Ursula B. Kaiser, Johanna Kluin-Nelemans, F Ong, Jo Hermans, P. F. H. Franck, S. Snijder |
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| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty biology medicine.diagnostic_test business.industry medicine.medical_treatment Hematology medicine.disease Gastroenterology Monoclonal gammopathy Unknown Significance Cytokine hemic and lymphatic diseases Internal medicine Immunopathology Immunoassay medicine biology.protein medicine.symptom Interleukin 6 business Multiple myeloma Progressive disease |
| Zdroj: | British Journal of Haematology. 107:132-138 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.1999.01669.x |
| Popis: | We determined interleukin-6 (IL-6) levels in the serum of 212 well-defined patients with newly diagnosed paraproteinaemia and evaluated its discriminatory value and prognostic role in multiple myeloma (MM). Results were compared with serum neural cell adhesion molecule and β-2-microglobulin, both established prognostic MM markers. Paraproteinaemia-related diagnoses were: MM (60), other haematological diseases (46), solid tumours (35), autoimmune diseases (17) and monoclonal gammopathy of unknown significance (MGUS) (54). The range of IL-6 levels in all diagnostic groups overlapped widely and did not serve as a discriminatory marker in newly diagnosed paraproteinaemia even when patients with infection or fever (42) were excluded. In MM high IL-6 levels (50 pg/ml) were not associated with a shorter survival (P = 0.24). We compared our results with 20 published studies on serum IL-6 in paraproteinaemia and/or MM. IL-6 data have to be related to the assay used (bio- or immunoassay) and to the status of MM (newly diagnosed, during therapy, progressive disease). We conclude that serum IL-6 is not specific for paraproteinaemia-related diseases and will not serve as a reliable discriminatory or prognostic marker in paraproteinaemia and MM. |
| Databáze: | OpenAIRE |
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