Generation of Non-Complement-Fixing, Blocking Factors by Lysosomal Extract Treatment of Cytotoxic Anti-Tumor Antibodies

Autor:	Michael J. Dauphinee, Norman Talal, Isaac P. Witz
Rok vydání:	1974
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 113:948-953
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.113.3.948
Popis:	Alloantibodies against EL-4 lymphoma and P-815 mastocytoma were raised by immunization of DBA/2 and C57BL/6 mice, respectively. Such antisera were capable of mediating complement-dependent cytotoxicity and of blocking specific killing by alloimmune lymphocytes. Treatment with lysosomal enzymes derived from the tumor decreased the ability of these alloantibodies to mediate complement-dependent cytotoxicity but left intact their blocking activity. Such degradation, if it were to occur, in vivo could contribute to enhanced tumor growth.
Databáze:	OpenAIRE
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