ChemInform Abstract: Double Carboxylation of O-Alkynyl Acetophenone with Carbon Dioxide

Autor:	Ming-Wang Yang, Hui-Bo Wang, Xu-Tong Yang, Wen-Zhen Zhang, Ling-Long Shi, Xiao-Bing Lu
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Carboxylation Chemistry Carbon dioxide Intramolecular cyclization Sequence (biology) General Medicine Medicinal chemistry Acetophenone
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201624128
Popis:	A copper-catalyzed double carboxylation of o-alkynyl acetophenone using carbon dioxide to afford 1(3H)-isobenzofuranylidene dicarboxylic esters in good yields is described. The reaction proceeds via a carboxylation/intramolecular cyclization/carboxylation sequence. Alkyl-substituted substrates show much higher double carboxylation product selectivities than aryl-substituted substrates.
Databáze:	OpenAIRE
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