A New Method for the Synthesis of Silicon- and Germanium-Containing 2-Acetylfurans and 2-Acetylthiophenes

Autor:	Luba Ignatovich, Juris Popelis, I. Shestakova, Edmunds Lukevics, Ilze Sleiksha, V. Romanov, S. Grinberga
Rok vydání:	2007
Předmět:	chemistry.chemical_compound chemistry Low toxicity Silicon chemistry.chemical_element Tumor cells Lithium Germanium General Medicine Cytotoxicity Carbonyl group Medicinal chemistry Derivative (chemistry)
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200747174
Popis:	A new method was developed for the synthesis of silicon-and germanium-containing acetylfurans and acetylthiophene by metallation of 2-acetylfuran or 2-acetylthiophene with n-BuLi at low temperature after protection of the carbonyl group with lithium N-methylpiperazide and reaction of the lithium derivative with various trialkyl-, alkylphenyl-, and cycloalkylchlorosilanes or trialkylchloro(bromo)germanes. The cytotoxic activity of the new compounds was studied, and it was established that the silicon-and germanium-containing acetylfurans and acetylthiophenes are substances with low toxicity (LD50 312->2000 mg/kg) and have low cytotoxicity toward HT-1080 and MG-22A tumor cells.
Databáze:	OpenAIRE
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