| Autor: |
D. V. Dayangi Hemalika, U.G. Chandrika, Ajith M. Abeysekera, Sameera Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.11.28.22282815 |
| Popis: |
BackgroundAs secretory phospholipase A2 (sPLA2) was shown to be elevated in patients who progress to severe dengue, it would be important to evaluate the usefulness of therapeutics that inhibit sPLA2 enzymes to prevent progression to severe dengue.ObjectivesTo explore the presence of sPLA2 inhibitors in plant extracts used in traditional medicine for treatment of fever in Sri Lanka.Study designAqueous and butanol extracts ofTragia hispida, Justicia adathodaand tubers ofCyperus rotunduswere screened for the presence of potential sPLA2 inhibitors using a commercial assay measuring sPLA2 activity.ResultsBoth the aqueous (THA) and butanol extracts (THB) ofTragia hispidahad sPLA2 inhibition levels comparable to the levels seen with the commercial sPLA2 inhibitor CAY10590. THB at concentrations of 0.1 µg/µL and 0.2 µg/µL, significantly reduced the sPLA2 activity (pConclusionsT. hispidaaqueous and butanol soluble fraction had potent sPLA2 inhibitory activities, which should be further explored for their potential to be used for treatment of dengue. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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