RADIATION-INDUCED DURAL FIBROSARCOMA WITH UNUSUALLY SHORT LATENT PERIOD
| Autor: | R. T. Leshner, N. R. Ghatak, F. Avdin |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Medulloblastoma
Cerebral Convexity business.industry medicine.medical_treatment Period (gene) Radiation induced General Medicine medicine.disease Pathology and Forensic Medicine Radiation therapy Cellular and Molecular Neuroscience Neurology medicine Neoplasm Neurology (clinical) Fibrosarcoma Nuclear medicine business Craniospinal |
| Zdroj: | Journal of Neuropathology and Experimental Neurology. 52:329 |
| ISSN: | 0022-3069 |
| DOI: | 10.1097/00005072-199305000-00275 |
| Popis: | Although rare, the occurrence of radiation-induced intracranial neoplasms of various types is well known. Among these tumors, fibrosarcomas, especially in the region of seila turcica, seem to be the most common type. These tumors characteristically occur after a long latent period, usually several years, following radiation therapy. The authors now report a case of apparently radiation-induced fibrosarcoma with some unusual features in a 10-year-old boy who was treated with radiation for medulloblastoma. He received a total dose of 53.2 Gy radiation delivered at 1.8 per fraction with 6 MV acceleration using the standard craniospinal technique. An MRI at 15 months after the completion of radiotherapy showed a mass over the cerebral convexity, which increased two-fold in size within a period of 4 months. A well circumscribed tumor was removed from the fronto-parietal convexity. The tumor measured 5x4.5x1.5 cm and was attached to the dura with invasion of the overlying bone. Histologically, it displayed the characteristic features of a low-grade fibrosarcoma. The patient remains free of tumor 18 months after the surgery. This case emphasizes the potential risk for the development of a second neoplasm following therapeutic radiation and also documents, to the authors' knowledge, the shortest latent period reported somore » far between administration of radiotherapy and development of an intracranial tumor.« less |
| Databáze: | OpenAIRE |
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