Effects of vitamin D repletion on glycemic control and inflammatory cytokines in adolescents with type 1 diabetes
| Autor: | Roshanak Monzavi, Colleen Azen, Steven D. Mittelman, Pisit Pitukcheewanont, Erin M. Shih |
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| Rok vydání: | 2014 |
| Předmět: |
Vitamin
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Internal Medicine medicine Vitamin D and neurology 030212 general & internal medicine education Glycemic education.field_of_study Type 1 diabetes business.industry medicine.disease Crossover study Endocrinology chemistry Pediatrics Perinatology and Child Health Glycated hemoglobin business |
| Zdroj: | Pediatric Diabetes. 17:36-43 |
| ISSN: | 1399-543X |
| DOI: | 10.1111/pedi.12238 |
| Popis: | Objective Little is known about the relationship between vitamin D deficiency and adolescents with type 1 diabetes. On the basis of adult studies showing that vitamin D improves insulin sensitivity and decreases inflammatory cytokines linked to microvascular complications, we hypothesized that treating vitamin D deficiency in adolescents with type 1 diabetes would improve glycemia and reduce inflammatory markers. Research design and methods This was a randomized, prospective, crossover study of 25 adolescents with type 1 diabetes for at least a year (aged: 13–21 yr; 62% female; 62% Hispanic) and vitamin D deficiency (25-OH vitamin D ≤30 ng/mL). Subjects received vitamin D3 (20 000 IU/week) for 6 months, either immediately or after 6 months of observation. Results At baseline, 63% of subjects screened were vitamin D deficient and randomized. Interleukin-6 (IL-6) was significantly higher in the vitamin D deficient group compared with the sufficient group (medians: 0.36 vs. 0.18) (p = 0.026), whereas neither C-reactive protein (CRP) nor tumor necrosis factor-α (TNF-α) differed. Vitamin D treatment increased serum levels of 25-OH vitamin D from 22 ± 5.3 to 34.3 ± 12.1 ng/mL (p < 0.01). However, treatment did not affect glycated hemoglobin (HbA1c), insulin dosage, CRP, interleukin-6 (IL-6), or TNF-α. Conclusions Vitamin D deficiency is prevalent in the adolescent type 1 diabetes population, and could be associated with changes in inflammatory markers. However, vitamin D repletion over 6 months did not affect glycemia or markers of inflammation in our study, highlighting the need for additional research to validate these findings. |
| Databáze: | OpenAIRE |
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