AN EXPERIMENTAL INVESTIGATION ON SUSTAINED DRUG DELIVERY OF RIBOFLAVIN

Autor:	J. Koteswararao, G M Madhu, V Venkatesham, G K MahadevaRaju, Sagar J S
Rok vydání:	2016
Předmět:	Drug business.industry media_common.quotation_subject 05 social sciences 050301 education Riboflavin Therapeutic index Targeted drug delivery Drug delivery Medicine Dosing Drug carrier business 0503 education Oral retinoid Biomedical engineering media_common
Zdroj:	International Journal of Research in Engineering and Technology. :43-48
ISSN:	2319-1163 2321-7308
DOI:	10.15623/ijret.2016.0527009
Popis:	The purpose of controlling drug delivery is to achieve more effective therapies while eliminating the potential for both under and over dosing and maintenance of concentration of drug in plasma within therapeutic index is very critical. The conventional Oral drug delivery has limitations and produce wide range of fluctuations of drug concentration in the bloodstream and tissues with consequent undesirable toxicity and poor efficiency and also repetitive dosing and unpredictable absorption. And hence the concept of oral Sustained release drug delivery systems has become prominent, which works on many different mechanisms. This work deals with the development of a sustained drug delivery system using riboflavin as the model drug in an IN-VITRO condition. A drug delivery system is fabricated using Poly Vinyl Alcohol (PVA). The effect of temperature and pH are considered to understand the effectiveness of the system. The results of experimental studies are compared with predictions from mass transfer model and Ritger-Peppas model and are in good agreement
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::585649dc86c7d207a9bd031870aff750 https://doi.org/10.15623/ijret.2016.0527009 Zobrazit plný text záznamu