| Autor: |
Morse, David L., Hruby, Victor J., Sessler, Jonathan L., Gillies, Robert J., Vagner, Josef, Sill, Kevin N., Barkey, Natalie M., Tafreshi, Narges K., Preihs, Christian |
| Rok vydání: |
2016 |
| Předmět: |
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| DOI: |
10.26153/tsw/3835 |
| Popis: |
The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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