UJI EFEKTIVITAS KOMBINASI EKSTRAK KULIT KAYU MANIS (Cinnamomum verum J. Presl) DAN DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DAN LDL PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN DAN PAKAN

Autor:	Hadi Sunaryo, Cipto Suriantika, Dwitiyanti Dwitiyanti
Rok vydání:	2019
Předmět:	biology Traditional medicine Cholesterol Insulin medicine.medical_treatment Atorvastatin Cinnamomum verum Blood lipids biology.organism_classification medicine.disease chemistry.chemical_compound Phaleria macrocarpa chemistry Diabetes mellitus Total cholesterol medicine medicine.drug
Zdroj:	JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X. 10
ISSN:	2355-696X 1412-1107
DOI:	10.35617/jfi.v10i2.586
Popis:	Deficiency insulin results increased of lipid in people with diabetes. It happens because of the disruption of insulin function as a result complications of high blood fat levels, especially cholesterol and triglycerides. This research was conduct to determine effec of the combination of Cinnamomum verum extract (KM) and Phaleria macrocarpa extract (MD) on decreasing of total cholesterol and LDL in rat. The research divided into 8 treatment groups that is normal, negative, positive, dose combination 1 (KM 300 mg/kg BB+MD 1000 mg/kg BB), dose combination 2 (KM 300 mg/kg BB+MD 500 mg/kg BB), dose combination 3 (KM 300 mg/kg BB+MD 250 mg/kg BB), dose combination 4 (MD 1000 mg/kg BB+KM 150 mg/kg BB), dose combination 5 (MD 1000 mg/kg BB +KM 75 mg/kg BB). Tukey test results showed a decrease in the optimal combination 4 with a percentage decrease in total cholesterol and LDL by 42.83% and 35.01% but the decline is not comparable to the positive control (atorvastatin) amounted to 47.13% and 47.15%.
Databáze:	OpenAIRE
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