Phytochemical analysis and cytotoxic activity of Petiveria alliacea (Phytolaccaceae)
| Autor: | Rodrigo Rodrigues de Oliveira, Fernanda Manhães Braga Gonçalves, Marina Meirelles Paes, Maria Raquel Garcia Vega, Queitilane de Souza Sales, Milton M. Kanashiro, Amaro Chaves Ramos |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antitumor activity Stigmastanol Folk medicine Stigmasterol 030102 biochemistry & molecular biology Traditional medicine biology Low toxicity biology.organism_classification 01 natural sciences Phytolaccaceae 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound Phytochemical chemistry Petiveria alliacea |
| Zdroj: | International Journal of Sciences. 2:52-58 |
| ISSN: | 2305-3925 2410-4477 |
| DOI: | 10.18483/ijsci.1000 |
| Popis: | Petiveria alliacea (Phytolaccaceae) is a small shrub which grows in Africa and tropical America, where it is popularly known as “tipim”, “tipi” and “guine”. The leaves are used in folk medicine as diuretic, sedative or analgesic. Phytochemical investigation led to the identification of eight compounds, six of which are being described for the first time in this species: stigmasterol, stigmastenol, stigmastanol, loliolide, 3-hydroxy-5,6-epoxy-β-ionone and benzyl-β-glucopyranoside. The hexane and dichloromethane fractions presented good antitumor activity besides low toxicity. The compounds isolated from the above mentioned fractions were also tested and showed good antitumor activity, which confirms a significant potential of steroids as antitumor agents. These results indicate the potential of P. alliacea as source of antitumor agents. |
| Databáze: | OpenAIRE |
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