Clinical outcomes of rare hepatocellular carcinoma variants compared to pure hepatocellular carcinoma
| Autor: | Christina Wu, Olatunji B. Alese, Joel P. Wedd, Mehmet Akce, Renjian Jiang, Bassel F. El-Rayes, Katerina Mary Zakka, Marty T. Sellers, Walid L. Shaib, Madhusmita Behera |
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| Rok vydání: | 2019 |
| Předmět: |
Surgical resection
medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Cancer Histology medicine.disease Multivariate survival Gastroenterology digestive system diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Hepatocellular carcinoma medicine Overall survival 030211 gastroenterology & hepatology business neoplasms Clear cell |
| Zdroj: | Journal of Hepatocellular Carcinoma. 6:119-129 |
| ISSN: | 2253-5969 |
| Popis: | Background HCC variants are rare primary hepatic tumors. The aim of this study is to compare clinical characteristics and outcomes of HCC variants with pure HCC. Methods Patients diagnosed between 2004 and 2013 with ICD-O-3 8180/3 and 8170/3-8175/3 were identified from the National Cancer Database. Univariate and multivariate survival analyses were conducted to analyze the association between histology and overall survival (OS). Results 80,280 patients were identified; pure HCC 78,461 (97.7%), fibrolamellar (FLHCC) 310 (0.4%), scirrhous 161 (0.2%), spindle cell 72 (0.1%), clear cell 487 (0.6%), pleomorphic 23 (0.0%), and combined HCC and cholangiocarcinoma (mixed HCC) 766 (1.0%). 76.7% were male and 72% Caucasian. Liver transplant was performed in 10.1% of pure HCC, 14.5% of mixed HCC, 16.2% of scirrhous, 6.9% of spindle cell, 8.8% of clear cell, 8.7% of pleomorphic, and 3.2% of FLHCC (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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