Rho-Signalgebung in der Tumorentstehung und -progression

Autor:	Monilola A. Olayioye, Janina Hendrick, Bettina Noll
Rok vydání:	2016
Předmět:	0301 basic medicine Cell growth Rho GTPases Cancer High resolution Biology medicine.disease Human genetics Cell biology GAP Proteins 03 medical and health sciences 030104 developmental biology medicine Tissue invasion Liver cancer Molecular Biology Biotechnology
Zdroj:	BIOspektrum. 22:369-372
ISSN:	1868-6249 0947-0867
DOI:	10.1007/s12268-016-0700-5
Popis:	Metastatic cancers are characterized by uncontrolled cell proliferation and tissue invasion, processes controlled by small Rho GTPases, the activation of which is regulated by GEF and GAP proteins. Deleted in liver cancer (DLC) proteins are such Rho regulators that are downregulated in different types of cancer. Using proteomic approaches, genetically encoded biosensors and high resolution microscopy, our lab studies how the DLC proteins control cellular Rho activity patterns in time and space.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::583ee8e4956e65c2056151e745b2e60b https://doi.org/10.1007/s12268-016-0700-5 Zobrazit plný text záznamu Full text from SpringerLink