Amelioration of adjuvant induced arthritis by apocynin

Autor:	K. A. Suri, Ghulam Nabi Qazi, Kiranjeet Kour, Anjali Pandey, Sarang Bani, Naresh Kumar Satti, Punita Sharma
Rok vydání:	2009
Předmět:	Pharmacology business.industry medicine.medical_treatment T cell Arthritis Vascular permeability medicine.disease Proinflammatory cytokine chemistry.chemical_compound Cytokine Immune system medicine.anatomical_structure chemistry Apocynin Immunology Medicine business Prostaglandin E
Zdroj:	Phytotherapy Research. 23:1462-1468
ISSN:	0951-418X
Popis:	The premise of the study was to investigate the antiarthritic potential of apocynin (APO) in Balb/c mice (in vivo). The experiment showed a dose-dependent decrease in oedema and showed a suppression of proinflammatory cytokines such as TNF-alpha and IL-1beta and mediators such as prostaglandin E(2) (PGE(2)) and LTB(4). At oral doses of 0.5, 1.0, 2.0 and 4.0 mg/kg once daily during the course of the experiment, APO induced an inhibition of T cell mediated immune response causing suppression of CD4+ and CD8+ T cells and of intracellular interferon-gamma (IFN-gamma) by flow cytometry in arthritic mice. In parallel there was a dose-dependent inhibition in vascular permeability causing an inhibition in the migration of leucocytes and exudate volume at the site of the inflammatory reaction. These observations validate the immunoregulatory potential of apocynin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5838286f0009b794cb9ced76503a44ce https://doi.org/10.1002/ptr.2803 Zobrazit plný text záznamu Plný text