PD04-06 CYTOREDUCTIVE NEPHRECTOMY IN THE TARGETED THERAPY ERA: AN ANALYSIS OF THE NATIONAL CANCER DATA BASE

Autor:	Michael Zavaski, Francisco Gelpi-Hammerschmidt, Maxine Sun, Jeffrey J. Leow, Steven L. Chang, Nawar Hanna, Alexander P. Cole, Toni K. Choueiri, Thomas Seisen, Quoc-Dien Trinh, Christian Meyer, Malte W. Vetterlein, Philip J. Cheng
Rok vydání:	2016
Předmět:	Oncology Gynecology Chemotherapy medicine.medical_specialty business.industry Urology medicine.medical_treatment Context (language use) Logistic regression medicine.disease Cancer data Targeted therapy Renal cell carcinoma Internal medicine medicine Cytoreductive nephrectomy Metastasectomy business
Zdroj:	Journal of Urology. 195
ISSN:	1527-3792 0022-5347
Popis:	INTRODUCTION AND OBJECTIVES: The treatment of metastatic renal cell carcinoma (mRCC) has profoundly changed over the last decade. There is little comprehensive evidence evaluating the role of metastasectomy (MSx) in in this context. We assessed trends and predictors of MSx and their impact on overall survival in a large national cohort. METHODS: The National Cancer Data Base from 1998-2012 was queried to identify 25455 mRCC patients with 5315 undergoing MSx. Covariates included the application of targeted chemotherapy (CTX) and immunotherapy (ITX). Baseline descriptive and multivariable logistic regression analyzes for prediction of MSx were conducted. Trends for chemo(CTX) and immunotherapy (ITX) as well as MSx were assessed using the annual percent change linear regression technique (EAPC). Kaplan-Meier curves and adjusted Cox-proportional hazard models assessed the impact of MSx on overall survival. RESULTS: Compared to controls, MSx patients were significantly younger (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::583272c107f9dc1f3ad32994ff3bebf8 https://doi.org/10.1016/j.juro.2016.02.2411 Zobrazit plný text záznamu