The ‘PAI-1 paradox’ in vascular remodelling
| Autor: | Isabel Diebold, Agnes Görlach, Steve Bonello, Damir Kraicun |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Endothelium Vascular disease business.industry medicine.medical_treatment Hematology Serpin medicine.disease Pulmonary hypertension Vascular remodelling in the embryo Pathogenesis medicine.anatomical_structure Fibrinolysis medicine Cancer research business Plasminogen activator |
| Zdroj: | Thrombosis and Haemostasis. 100:984-991 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th08-08-0524 |
| Popis: | SummaryVascular remodelling isa complex phenomenon associated with restructuring of the vessel wall as a consequence of disruption of vascular homeostasis. Alterations of the vascular wall have been linked to a variety of cardiovascular disorders including atherosclerosis, vascular injury and pulmonary hypertension. Plasminogen activator inhibitor-1 (PAI-1) is a member of the serpin (serine proteinase inhibitor) family and acts as an important inhibitor of fibrinolysis by interfering with the plasminogen system. In addition to its anti-fibrinolytic effects, PAI-1 appears to modulate cellular responses linked to vascular remodelling. Since PAI-1 levels have been shown to be altered in various disorders associated with vascular remodelling of the systemic and pulmonary vascular bed, this serpin may playa pivotal role in the pathogenesis of these diseases. |
| Databáze: | OpenAIRE |
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