Specific detection of Helicobactor pylori and non-Helicobactor pylori flora in small-and large-cell primary gastric B-cell non-Hodgkin's lymphoma
| Autor: | R. W. Stockbrügger, I. A. M. Gisbertz, F. J. Bot, J. W. Arends, D. M. A. E. Jonkers, Harry C. Schouten, L. W. Vrints |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Pathology biology business.industry Gastric lymphoma Large cell Large-cell lymphoma MALT lymphoma Hematology Helicobacter pylori bacterial infections and mycoses biology.organism_classification medicine.disease Gastroenterology Non-Hodgkin's lymphoma Oncology Internal medicine medicine business B-cell lymphoma Diffuse large B-cell lymphoma |
| Zdroj: | Annals of Oncology. 8:S33-S36 |
| ISSN: | 0923-7534 |
| Popis: | Background: Primary gastric non-Hodgkin's lymphomas possibly develop in response to local infection by Helicobacter pylori (H. pylori). We investigated the presence of H. pylori and non-H. pylori flora histologically in small- and large-cell primary gastric lymphoma using a specific staining method. Materials and methods: Specimens of 52 cases of primary gastric lymphoma (17 small cell, 35 large cell) were stained with modified Giemsa (MG) and immunohistochemically using a polyclonal antibody against H pylori (IHC). Results: Thirty-two cases (61.5%) (small cell 76% versus large cell 53%, P > 0.05) showed immunoreactivity for H pylori in the mucosa surrounding the tumor. Remarkably, there was localization of H pylori in the neck of the gastric glands in 3 cases. Non-H pylori flora was seen in 35 cases (76.3%) (small cell 53% versus large cell 74%, P > 0.05). In 20 cases. this non-H. pylori flora was mixed with H. pylori. Five cases showed no bacterial flora at all. Conclusions: (1)Using immunohistochemistry, the prevalence of gastric lymphoma cases with H. pylori (61.5%) approximates that of H. pylori in the normal population. (2) No statistical difference was found between the occurrence of H. pylori and non-H pylori bacterial flora in small- versus large-cell lymphoma. (3) Our results suggest that H. pylori may not be the only etiologic factor in primary gastric lymphoma. |
| Databáze: | OpenAIRE |
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