Acute Thoracic Syndrome in Sickle Cell Children at the Pediatrics Department of Donka National Hospital

Autor: Mamadou Pathé Diallo, Mamadou Moustapha Diop, Mamadou Aliou Doukoure, Saliou Bella Diallo, Ibrahima Koolo Barry, Hasmiou Dia, Emmanuel Camara, Mohamed Lamine Diallo, Mamadou Ciré Barry, N. V. Gateu Tadjom, Aissata Barry
Rok vydání: 2020
Předmět:
Zdroj: Open Journal of Pediatrics. 10:688-694
ISSN: 2160-8776
2160-8741
DOI: 10.4236/ojped.2020.104071
Popis: Introduction: Acute thoracic syndrome is the appearance of a new pulmonary infiltrate on radiology associated with fever, desaturation or respiratory signs. It is the second leading cause of hospitalization and the first cause of death in sickle cell patients. It is an acute pulmonary complication whose pathophysiological mechanisms are still poorly understood. This study aims to study the epidemiological, clinical, therapeutic and evolutionary aspects of Acute Chest Syndrome in children at the Pediatrics Department of Donka National Hospital. Method: This is a prospective study of descriptive type for a period of 6 months from February 19 to August 19, 2019 on patients with sickle cell disease who developed an ATS in the pediatrics department of Donka National Hospital. Epidemiological, clinical, therapeutic and evolutionary data were studied and proportionate data were calculated. Results: The frequency of ATS was 39%. The mean age of our patients was 9.83 years with the extremes of 4 and 16 years. The age group from 6 to 10 years with a frequency of 66.7% was the most affected. Fever was the main clinical manifestation, followed by hepatomegaly. All our patients were homozygous SS and undergoing folic acid prophylaxis. 96% of our patients did not receive any specific vaccine. Antibiotic therapy, hyperhydration and analgesics were administered to all our patients. 96% of our patients were transfused with red blood cell concentrate. 96% of our patients were transfused with packed red blood cells. 96% of our patients were transfused with packed red blood cells and 96% of them had a favorable outcome. Conclusion: ATS is an acute complication of sickle cell disease responsible for significant mortality and morbidity in the pediatric population. Its treatment is symptomatic and must be started early. Emphasis must be placed on prevention to prevent or limit its occurrence.
Databáze: OpenAIRE