Improving isotope ratio precision in inductively coupled plasma quadrupole mass spectrometry by common analyte internal standardization

Autor:	Ramon M. Barnes, Assad S. Al-Ammar
Rok vydání:	2001
Předmět:	Analyte Isotope Chemistry Analytical chemistry Natural abundance Thermal ionization mass spectrometry Isotope dilution Mass spectrometry Analytical Chemistry Degree of ionization Quadrupole Physics::Atomic Physics Nuclear Experiment Spectroscopy
Zdroj:	J. Anal. At. Spectrom.. 16:327-332
ISSN:	1364-5544 0267-9477
DOI:	10.1039/b100973g
Popis:	The common analyte internal standardization (CAIS) chemometric technique is extended to improve isotope ratio precision obtained by inductively coupled plasma-quadrupole mass spectrometry (ICP-QMS). A correction function for isotope ratio measurement is derived from a relationship of mass sensitivity as a function of element mass after considering the degree of ionization and isotopic abundance. An analyte isotope ratio correction factor can be determined by simultaneously measuring several internal reference isotopic ratios and the analyte. The CAIS approach corrects for isotopic mass bias and isotope ratio variation with sample matrix concentration. Isotope ratio precision is improved from about 0.4 to 0.05%, because long-counting times allow correcting mass bias and isotope ratio drift during extended data-acquisition periods. Isotope ratio accuracy is improved from 0.2 to 0.02%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58219c60917dfa32f7743c8e547e77cd https://doi.org/10.1039/b100973g Zobrazit plný text záznamu