Kidney function in oncologic patients after cisplastin chemotherapy

Autor:	Hozhenko Ai, Sirman Vm, Moskalenko Om, Storozhenko Sa, ZhiZhnievs'ka Oo
Rok vydání:	2012
Předmět:	Cisplatin Chemotherapy Creatinine Kidney medicine.medical_specialty Physiology business.industry medicine.medical_treatment Urology Renal function Nephrotoxicity Excretion chemistry.chemical_compound medicine.anatomical_structure chemistry medicine business Homeostasis medicine.drug
Zdroj:	Fiziolohichnyĭ zhurnal. 58:72-76
ISSN:	2522-9036 2522-9028
DOI:	10.15407/fz58.03.072
Popis:	During examination of kidney function under cisplastin chemotherapy in oncologic patients the nephrotoxicity of the drug have been shown during 24 hours after administration. We found that in 24 hours after injection ofcisplastin in the dose 50 mg/m2 of the surface of the body, the excretion of creatinine, sodium, potassium, osmotic active compounds and chlorides is increased more than two times, indicating for disorder in osmolality, volume and ionic regulation of kidney function. The determined peculiarities are consequences of kidney injuries, which are confirmed by an increase in erythrocyte- and leucocyteuria. We showed that alterations in homeostatic kidney function is due to damage of renal tubules. Our study necessitates a need for renal protection during the whole period of cisplastin chemotherapy.
Databáze:	OpenAIRE
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