Elemental fluorine. Part 19: Electrophilic fluorination of hexyl derivatives bearing electron withdrawing groups

Autor:	Emmanuelle Thomas, Jelena Trmcic, John S. Moilliet, Graham Sandford, Richard D. Chambers, Mandy Parsons
Rok vydání:	2006
Předmět:	chemistry.chemical_classification Electrophilic substitution chemistry Organic Chemistry Drug Discovery Electrophilic fluorination Polar effect Fluorine Organic chemistry chemistry.chemical_element Biochemistry Medicinal chemistry Alkyl
Zdroj:	Tetrahedron. 62:7162-7167
ISSN:	0040-4020
Popis:	Reaction of a series of model hexyl derivatives of the form C6H13–X (X=Cl, Br, I, CO2Me, COMe, CHO) with both elemental fluorine and Selectfluor™ was studied in order to assess the impact of electron withdrawing functional groups upon fluorination of an alkyl chain. Fluorination generally occurs at secondary sites, with a slight preference for those that are furthest removed from the electron withdrawing group, consistent with an electrophilic substitution process, although mixtures of fluorinated products are obtained in most cases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::581fded0242fab68ce342f81dfb88c3a https://doi.org/10.1016/j.tet.2006.03.113 Zobrazit plný text záznamu Full Text from ScienceDirect