| Autor: |
Mohammed Yosri, Inas M. Abou El-Enain, Nermine N. Abed, Eman E. Helal, Eman S. Abdelkhalek, Waleed Suleiman, Nesreen A. Safwat |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Recent Advances in Anti-Infective Drug Discovery. 18 |
| ISSN: |
2772-4344 |
| DOI: |
10.2174/2772434418666230427165013 |
| Popis: |
Background: The most significant sexually transmissible fungal disease, semen candidiasis, is caused by Candida albicans and impacts male reproductive potential. Actinomycetes are a group of microorganisms that could be isolated from various habitats and used for the biosynthesis of various nanoparticles with biomedical applications. Objective: Testing antifungal activity of biosynthesized Ag nanoparticles versus isolated C. albicans from semen as well as its anticancer activity versus the Caco-2 cell line. Methods: Screening 17 isolated actinomycetes for the biosynthesis of Ag nanoparticle biosynthesis. Characterization of biosynthesized nanoparticles, testing its anti-Candida albicans, and antitumor activity Results: Streptomyces griseus was the isolate that identified silver nanoparticles using UV, FTIR, XRD and TEM. Biosynthesized nanoparticles have promising anti-Candida albicans with MIC (125 ± 0.8) µg/ml and accelerate apoptotic rate versus Caco-2 cells (IC50 = 7.30 ± 0.54 µg/ml) with minimal toxicity (CC50 = 142.74 ± 4.71 µg/ml) versus Vero cells. Conclusion: Certain actinomycetes could be used for the biosynthesis of nanoparticles with successive antifungal and anticancer activity to be verified by in vivo studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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